Journal article
Responsiveness of Critically Ill Adults with Multimorbidity to Rehabilitation Interventions: A Patient-Level Meta-Analysis Using Individual Pooled Data from Four Randomized Trials
JRA Jones, A Karahalios, ZA Puthucheary, MJ Berry, DC Files, DM Griffith, LA McDonald, PE Morris, M Moss, A Nordon-Craft, T Walsh, S Berney, L Denehy
Critical Care Medicine | LIPPINCOTT WILLIAMS & WILKINS | Published : 2023
Abstract
OBJECTIVE: To explore if patient characteristics (pre-existing comorbidity, age, sex, and illness severity) modify the effect of physical rehabilitation (intervention vs control) for the coprimary outcomes health-related quality of life (HRQoL) and objective physical performance using pooled individual patient data from randomized controlled trials (RCTs). DATA SOURCES: Data of individual patients from four critical care physical rehabilitation RCTs. STUDY SELECTION: Eligible trials were identified from a published systematic review. DATA EXTRACTION: Data sharing agreements were executed permitting transfer of anonymized data of individual patients from four trials to form one large, combine..
View full abstractGrants
Awarded by National Institutes of Health
Funding Acknowledgements
This work is supported by an Austin Medical Research Foundation Grant (Drs. Jones and Berney). Dr. Jones received funding from an Australian Government Research Training Program Scholarship for the submitted work. Drs. Berney and Denehy received funding from the National Health and Medical Research Council (grant no. 454717), Physiotherapy Research Foundation, Austin Medical Research Foundation, and Australian and New Zealand Intensive Care Society related to the submitted work. Drs. Moss and Nordon-Craft received funding from the National Institute of Nursing Research (NINR, grant no. R01 NR011051) and the National Heart, Lung, and Blood Institute (NHLBI, grant no. K24 HL089223) from the National Institutes of Health (NIH) related to this work. Drs. Morris, Berry, and Files received funding from the NIH/NINR/NHLBI related to this work. Dr. Files received funding from Global Blood Therapeutics and Medpace Data and Safety Monitoring Board. Drs. Walsh and Griffith received funding from the Chief Scientist Office, Scotland (grant no. CZH/4/531) related to this work. Dr. Griffith's institution received funding from Fresenius-Kabi and BBraun.